Title Astmos uždegiminio branduolio faktoriaus kapa B kelio genetinių ir biocheminių žymenų bei jų sąsajų paieška
Translation of Title The search of genetic and biochemical markers of asthma inflammatory nuclear factor kapa B pathway
Authors Balčiūnaitė, Živilė
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Pages 118
Keywords [eng] Asthma ; Proteasome endopeptidase complex ; Polymorphism, genetic
Abstract [eng] [...]. Aim of the study. The aim of this study was to evaluate genetic and biochemical markers of asthma inflammatory pathway and to estimate possible associations. Study objectives: 1. To evaluate polymorphisms of proteasome genes (PSMA6, PSMC6 and PSMA3) in patients with asthma and compare to healthyt subjects. And to estimate the associations of alleles, genotypes and haplotypes with asthma. 2. To evaluate polymorphisms of nuclear factor kappa B (NFKB1) and its inhibitor alpha (NFKBIA) genes in patients with asthma and compare to healthy subjects. And to estimate the associations of alleles, genotypes and haplotypes with asthma. 3. To evaluate serum concentration of 26S proteasome and NF-κB nuclear factor in blood serum of patients with asthma and compare to healthy subjects. 4. To estimate possible associations between genetic and biochemical markers. [...].
Published Kaunas : Lietuvos sveikatos mokslų universitetas
Dissertation Institution Lietuvos sveikatos mokslų universitetas
Type Doctoral Thesis
Language Lithuanian
Publication date 2018