||The aim: to model topical semisolid dosage forms with the extract of the trifid bur-marigold (Bidens tripartita L.) herb and to evaluate their quality by carrying out biopharmaceutical tests. Objectives: 1. To prepare a suitable extract of the trifid bur-marigold herb. 2. To evaluate the demand of formulations with trifid bur-marigold for skincare and to model semisolid dosage forms with the trifid bur-marigold liquid extract. 3. To evaluate the quality of semisolid dosage forms with the trifid bur-marigold liquid extract. 4. To estimate the influence of the excipients and the category of the semisolid dosage form on the results of in vitro release test of active compounds. 5. To select the semisolid dosage form with the best quality and to optimise its composition. Methods: the qualitative analysis of the liquid extract of trifid bur-marigold was conducted spectrophotometrically, by determining the total amount of the phenolic compounds. Quantitative composition of the liquid extract of trifid bur-marigold was analysed by using high performance liquid chromatography. The quality of the semisolids was evaluated by measuring pH values, rheological properties and by testing the release of active compounds in vitro. The object of the study: the topical semisolid dosage forms with the trifid bur-marigold extract. Results: experimental semisolid dosage forms with the liquid extract of trifid bur-marigold with pH values from 6.02 ± 0.01 to 8.93 ± 0.01 were modelled. The highest coefficient of consistency at the temperature of 20 ºC was estimated for gels (277.2 ± 0.37 (Pa·s)n), whereas for W/O creams (from 25.61 ± 0.28 to 220.6 ± 0.35 (Pa·s)n) it was lower. The highest rate of phenolic release and the highest amount of active compounds after a 6-hour in vitro release test were established in W/O cream N1 (1.61 ± 0.04 mg/cm2 and 15.65 ± 0.14 μg/ml). After optimising the composition, it was determined that the optimal composition was 20.0% of cetostearyl alcohol, 12.5% of shea butter, 18.75% of glycerol, 18.75% of almond oil and 30.0% of liquid extract of trifid bur-marigold. Conclusions: the results of the experimental research revealed that the category of the semisolid dosage form and the excipients, used in semisolids, influence the pH value, rheological properties and the release kinetics of active compounds. The rheological properties of W/O creams depend on temperature, whereas the rheological properties of gels were not influenced by it. In addition, the increase of the viscosity of semisolids, decreases the release of active compounds.