||Research aim: to assess the risk of operating room nurses injuries with needles and other sharp instruments. Research object: operating room nurses injuries with needles and other sharp instruments. Research objectives: 1. To asses frequency, type and reasons of operating room nurses injuries with needles and other sharp instruments. 2. To analyse influencing causes for safe operating room environment. 3. To analyse the operating room nurses attitudes towards registration and reporting of injuries inflicted by needles and other sharp instruments. Research methodology: Research was done in January–April 2013 in Vilnius and Kaunas 3rd level hospitals. For this research two types of questionnaires, written by German scientist Dr. Sabine Wicker, were used: „Incidental Injury“ („Ein stich Stecktan“) and „Minimizing the danger of infection – prevent the needle puncture“ (,,Infektionsrisiken senken – Nadelstichverletzungen vermeiden“). Questionnaires were translated to Lithuanian language. There were 200 questionnaires distributed in total, 185 of them were returned and 10 were not fully answered. 175 fully answered questionnaires were used for statistical analysis. SPSS 17.0 and Microsoft Excel programs were used for statistical data analysis. Statistical data meaningfulness was verified by chi quadrant (χ2) criteria and statistical meaningfulness. Data difference is meaningful when p<0,05. Factor analysis method was used for the research. Results and conclusions: During the analysis of the data, it was seen, that there was no operating room nurse who wouldn‘t have had and injury inflicted in a workplace among all the respondents, during their entire career. Puncture of a needle was the most common injury for the respondents (40,6 percent, n=71). Working tools were contaminated in most cases of an injury (46,3 percent, n=81). While assessing the severity of an injuries encountered by operating rooms nurses it was seen that most of them were surface injuries 48,6 percent (n=85). According to the data, in most cases operating room nurses inflicted an injury because of hurrying or rushing – 69,1 percent (n=121). 60 percent (n=105) of nurses have registered their injuries. Main causes why nurses didn‘t register their injuries: thinking that injury was minor (64,3 percent, n=45), registration of an injury will help no one (51,4 percent, n=36); heavy workload (50 percent, n=35), etc. One third of the respondents thought that patient is not infected with HBV.