||Objective: to model topical semisolid dosage forms with soft extract of propolis and to evaluate their quality by carrying out the biopharmaceutical tests. Tasks: 1. To select multiple formulations for the production of ointments and creams according to the scientific literature, for the treatment of atopic dermatitis; 2. To make stable topical semisolid systems with soft extract of propolis and to evaluate their quality by investigating these parameters: physico-chemical properties, homogeneity and rheological properties; 3. To evaluate quality of modeled creams and ointments with propolis, based on the results of in vitro release test of active compounds; 4. To evaluate how the release of active compounds is influenced by the choice of the base of modelled creams or ointments. Methods: qualitative analysis of the soft extract of propolis was evaluated spectrophotometrically by determining the total content of polyphenolic compounds. Quantitative composition of the soft extract of propolis was analyzed using high performance liquid chromatography. Quality of the creams (water-in-oil emulsions) and ointments was evaluated by measuring pH values, rheological properties, homogeneity and by testing the release of active compounds in vitro. The object of the study: topical semisolid dosage forms with soft extract of propolis. Results: modeled topical semisolid dosage forms with soft extract of propolis are stable with pH values of 4,07 to 6,44, a consistency coefficient (K) values at a room temperature – of 21,64 to 412,13 Pa·sn. In vitro release studies showed that after 6 hours of the release test, ointment formulations released up to 5,4 percent of active compounds, while the creams (water-in-oil emulsions) released up to 10,85 percent of active compounds. Conclusions: release studies have shown that the chosen semisolid dosage forms and selected auxiliary materials influence the pH value, rheological characteristics and the release kinetics of phenolic compounds in the semisolid dosage forms. More active compounds are released from water-in-oil emulsion bases, than from the ointments.